Eflornithine hydrochloride Monohydrate

Research use only, not for human use.

Eflornithine hydrochloride, hydrate (DFMO; MDL-71782) is a drug found to be effective in the treatment of facial hirsutism.

Eflornithine hydrochloride, hydrate (DFMO; MDL-71782) is a drug found to be effective in the treatment of facial hirsutism.(In Vivo):Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.

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Eflornithine is the only new molecule registered for the treatment of human African trypanosomiasis over the last 50 years. It is the drug used mainly as a back-up for melarsoprol refractory Trypanosoma brucei gambiense cases. In subjects with excessive, unwanted facial hair, eflornithine 15% cream is superior to placebo in reducing hair growth. After 24 weeks' treatment, 58% of eflornithine and 34% of placebo subjects have at least some improvement in facial hirsutism. The hair growth inhibitory activity of eflornithine is significantly enhanced when the eflornithine cream is applied onto a mouse skin area pretreated with microneedles. Treatment of coarctation hypertensive rats with eflornithine results in a normalization of the contractile intensity to KCI and norepinephrine and relaxations to acetylcholine by 14 days of hypertension.

DFMO | Eflornithine

Others

Other Targets

Others

Other Indications

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96020-91-6

236.64

C6H15ClF2N2O3

>98% (HPLC)

Soluble in DMSO

O.Cl.NCCCC(N)(C(F)F)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years